6-amino-spiro¬penam-2,4'-piperidine|-3- carboxylic acid...

Details 6-amino-spiro¬penam-2,4'-piperidine|-3- carboxylic acid... 6-amino-spiro¬penam-2,4'-piperidine|-3- carboxylic acid...

C - Chemistry, Metallurgy

07

D

260/111

C07D 499/44 (2006.01) C07D 499/00 (2006.01)

Patent

CA 1148144

ABSTRACT OF THE DISCLOSURE 6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acid derivatives having the formula Image wherein R is a methyl, phenyl or benzyl radical, Z1 is a hydrogen atom and Z2 is a radical selected from those known from penicillin chemistry and is preferably a 2- phenylacetyl, 2-amino-2-phenylacetyl, 5-methyl 3-phenyl- 4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl radical, or Z1 and Z2 together represent a bivalent radical Z3 and preferably a (hexahydro-lH-azepin-1-yl)-methylene radical, as well as the pharmaceutically acceptable non-toxic salts thereof and process for preparing the same. These compounds have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infec- tious diseases caused by Gram-positive and Gram-negative bacteria.

354562

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