6-amino-spiro¬penam-2,4'-piperidine|-3- carboxylic acids

Details 6-amino-spiro¬penam-2,4'-piperidine|-3- carboxylic acids 6-amino-spiro¬penam-2,4'-piperidine|-3- carboxylic acids

C - Chemistry, Metallurgy

07

D

260/111

C07D 499/42 (2006.01) C07D 499/00 (2006.01) C07D 513/10 (2006.01)

Patent

CA 1148145

A B S T R A C T o f t h e D I S C L O S U R E 6-Amino-spiro[enam-2,4'-piperidine]-3-carboxylic acids, salts and esters thereof of the formula Image wherein R1 is hydrogen, benzyl or an alkali metal or ammonium ion and R2 is methyl, phenyl or benzyl and process for preparing the same. These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to penicillins, besides own antibiotic activity with a broad antibacterial spectrum. Therefore, they are useful as antibacterials agents and as therapeutic agents for humans and for animals in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

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