6- and 7-amino isoquinoline compounds and methods for making...

Details 6- and 7-amino isoquinoline compounds and methods for making... 6- and 7-amino isoquinoline compounds and methods for making...

C - Chemistry, Metallurgy

07

D

C07D 217/02 (2006.01) A61K 31/4709 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2712443

6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Phar-maceutical compositions including therapeutically effective amounts of the 6- and 7- aminoisoquinoline compounds and pharma-ceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.

L'invention concerne des composés de 6-aminoisoquinoléine et 7-aminoisoquinoléine destinés à influencer, inhiber ou réduire l'action d'une kinase. Des compositions pharmaceutiques comprenant des quantités thérapeutiquement efficaces de composés de 6-aminoisoquinoléine et 7-aminoisoquinoléine et des vecteurs pharmaceutiquement acceptables sont également décrits. Divers procédés utilisant les composés et/ou les compositions afin d'influencer des états pathologiques tels que le cancer, l'obésité et le glaucome sont également fournis.

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