6-and/or 7-substituted-1,2,3,4,4a...

Details 6-and/or 7-substituted-1,2,3,4,4a... 6-and/or 7-substituted-1,2,3,4,4a...

C - Chemistry, Metallurgy

07

D

260/361

C07D 307/91 (2006.01) C07D 307/77 (2006.01)

Patent

CA 2025479

89/VJClA 17970 TITLE OF THE INVENTION 6- AND/ OR 7-SUBSTITUTED-1,2,3,4,4a,9b- HEXAHYDRO-8-HYDROXYDIBENZOFURAN-3-OLS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS ABSTRACT OF THE DISCLOSURE Positions 7-and/or 6-substituted 1,2,3,4,4a,9b-Hexahydro-8-hydroxydibenzofuran-3-ols and analogs of that general structure are described. These compounds are found to be potent inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukotrienes and useful in the treatment of a variety of inflammatory conditions.

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