6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agents

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2537520

This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.

L'invention porte sur certaines 6-aryl-7-halo-imidazo[1,2-a]pyrimidines, sur leurs sels pharmacocompatibles, et sur des compositions les contenant, agissant en tant qu'agents anticancéreux pour traiter le cancer des mammifères en favorisant la polymérisation des microtubules. L'invention porte également sur une méthode de traitement ou d'inhibition de la croissance de cellules tumorales, et de traitement ou prévention des cellules cancéreuses présentant une résistance aux multithérapies ou du fait de multithérapies, ladite méthode consistant à administrer aux mammifères le nécessitant une dose efficace desdits composés ou de leurs sels pharmacocompatibles.

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