6-aryloxy-2-oxo-1-aza-4-oxa (or thia)-spiro 4,5 decanes

Details 6-aryloxy-2-oxo-1-aza-4-oxa (or thia)-spiro 4,5 decanes 6-aryloxy-2-oxo-1-aza-4-oxa (or thia)-spiro 4,5 decanes

C - Chemistry, Metallurgy

07

D

260/310.1, 260/3

C07D 498/10 (2006.01) C07C 45/71 (2006.01) C07D 263/52 (2006.01) C07D 277/60 (2006.01) C07D 513/10 (2006.01)

Patent

CA 1051438

ABSTRACT OF THE DISCLOSURE: 6-Aryloxy-2-oxo-1-aza 4-oxa-(or thia)-spiro [4,5]decanes having the general formula: Image (I) wherein X represents a hydrogen or halogen atom or a lower alkyl, A represents an oxygen or sulfur heteroatom and R1 and R2 are identical or different and each represents a hydrogen atom, a lower alkyl or phenyl radical, are obtained by condensing in an aromatic solvent and in the presence of an ammonium salt and a dehydrata- tion catalyst, substantially equimolar amounts of a 2-phenoxy- cyclohexanone of the formula: Image wherein X has the aforesaid meaning, and an acid of the formula: Image wherein A, R1 and R2 have the aforesaid meanings; the condensation is effected by heating to reflux until the theoretical amount of formed water is entirely collected by means of the azeotrope formed in the solvent. The compounds of formula (I) are useful as stimulating agents for vigilance, as psycho-stimulators and genesic stimulators.

236083

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