C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 253/075 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 31/55 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 405/12 (2006.01) C07D 409/00 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/00 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/00 (2006.01) C07D 417/12 (2006.01) C07D 451/02 (2006.01) C07D 451/06 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07D 471/08 (2006.01) C07D 471/10 (2006.01) C07D 4
Patent
CA 2321380
The present invention provides novel compounds of the Formula I (see formula I) and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R1 to R8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, overweight condition, hyperlipidemia, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression, osteoporosis, cardiac arrhythmias, glaucoma and congestive heart failure are also provided.
Chiang Yuan-Ching Phoebe
Dow Robert Lee
Estep Kimberly Gail
Pfizer Products Inc.
Smart & Biggar
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