6-azido-decohydro-4a phenyl-cis-isoquinoline compounds

Details 6-azido-decohydro-4a phenyl-cis-isoquinoline compounds 6-azido-decohydro-4a phenyl-cis-isoquinoline compounds

C - Chemistry, Metallurgy

07

D

260/277.1, 260/2

C07D 405/06 (2006.01) C07D 217/00 (2006.01) C07D 217/02 (2006.01) C07D 217/04 (2006.01) C07D 217/06 (2006.01) C07D 217/16 (2006.01)

Patent

CA 1118775

Abstract of the Disclosure The present invention provides compounds of formula I Image I Wherein R1, R2 and R3 are chosen from the following signi- ficances (1), (11) and (111):- (1) R1 and R2, independently, are hydrogen (C1-6)alkyl, trifluoromathyl, halogen, or (C1-4)alkoxym, and R3 is hydrogen, or (11) (a) R1 and R2, independently, are hydrogen, (C1-6)alkyl, trifuloromethyl or halogen, or (b) R1 is (C1-4)alkoxy and R2 is (C1-6)alkyl, trifluoromethyl, halogen or (C1-4)alkoxy, and R3 is (C1-6) alkyl, a radical of formula II, -CH2.CH=CR4R5 II wherein R4 and R5,independently, are hydrogen or (C1-4)alkyl, a radical of formula III, Image m wherein m is 2,3 or 4, a radical of formula IV Image IV wherein n is 1or 2, or a radical of formula V Image wherein p is 1 or 2 and R6 is hydrogen, halogen, trifluoromathyl, (C1-4)alkoxy, (C1-4)alkyl, amino, di[(C1-4)alkyl] amino (C1-4)alkylamino, or (III) the amino group is cis to the phenyl group, R1 is (C1-4)alkoxy in the meta position R2 is hydrogen, and R3 is methyl. are useful analgesic agents.

323128

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