6.beta., 7.beta.;15, 16-dimethylene-1,4-androstadien-...

Details 6.beta., 7.beta.;15, 16-dimethylene-1,4-androstadien-... 6.beta., 7.beta.;15, 16-dimethylene-1,4-androstadien-...

C - Chemistry, Metallurgy

07

J

260/21, 260/39

C07J 9/00 (2006.01) C07J 21/00 (2006.01) C07J 53/00 (2006.01)

Patent

CA 1134814

ABSTRACT The invention provides a 6.beta.,7.beta.;15,16-dimethylene- 1,4-androstadien-3-one of the general formula Image I in which the 15,16-positioned methylene group may be in the .alpha.- or .beta.-configuration and E represents a group of the formula Image , Image or Image , and a process for the preparation thereof. Compounds of the invention have useful pharmaco- logical properties, being, inter alia, diuretics of the aldosterone-antagonist type. Accordingly, the invention also provides a pharmaceutical preparation containing a compound of the general formula I.

353151

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