6-.beta.-substituted penicillanic acids as .beta.-lactamase...

Details 6-.beta.-substituted penicillanic acids as .beta.-lactamase... 6-.beta.-substituted penicillanic acids as .beta.-lactamase...

C - Chemistry, Metallurgy

07

D

260/118.5

C07D 499/00 (2006.01) A61K 31/43 (2006.01) A61K 31/545 (2006.01)

Patent

CA 1154011

ABSTRACT OF THE DISCLOSURE 6-.beta.-iodo-substituted penicillanic acids and derivatives thereof as useful enhancers of the effectiveness of several .beta.- lactam antibiotics against many .beta.-lactamase producing bacteria, and 6-.beta.-iodo-substituted penicillanic acid derivatives wherein the carboxy group is protected by a conventional penicillin carboxy protecting group as useful intermediates leading to said synergistic agents. A process for converting 6,6-diiodo- penicillanic acid derivatives to the corresponding 6-.beta.-iodo- substituted penicillanic acid congeners.

346906

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