6-(c2-6alkylseleno)purines and methods for treating neural...

Details 6-(c2-6alkylseleno)purines and methods for treating neural... 6-(c2-6alkylseleno)purines and methods for treating neural...

C - Chemistry, Metallurgy

07

D

C07D 473/00 (2006.01) A61K 31/52 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2726587

The present application relates to anti-viral selenopurine compounds of formula (I) : wherein R1 is C2-6alkyl, and pharmaceutically acceptable salts, solvates, and prodrugs thereof. These 6-(C2- 6alkylseleno)purine compounds find use in the treatment of neural measles virus infection and associated diseases (namely, multiple sclerosis or neural measles). A particularly preferred compound is ethylselenopurine or ESP.

La présente invention porte sur des composés sélénopuriniques antiviraux représentés par la formule (I), dans laquelle R1 représente un groupe alkyle en C2-6, ainsi que sur les sels de qualité pharmaceutique, solvates et promédicaments de ceux-ci. Ces composés de 6-(C2- 6alkylséléno)purine sont utilisés dans le traitement d'infections neuronales dues au virus de la rougeole, ou d'une maladie associée à celles-ci (par exemple, la sclérose en plaques ou les infections neuronales dues au virus de la rougeole). Un composé particulièrement préféré est l'éthylsélénopurine, ou l' ESP.

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