6-fluoro-7-chloro-1-methylamino-4-oxo-1-4-dihydroquinoline...

Details 6-fluoro-7-chloro-1-methylamino-4-oxo-1-4-dihydroquinoline... 6-fluoro-7-chloro-1-methylamino-4-oxo-1-4-dihydroquinoline...

C - Chemistry, Metallurgy

07

F

260/283, 260/266

C07F 5/02 (2006.01) C07D 401/10 (2006.01) C07F 5/04 (2006.01)

Patent

CA 1282068

A B S T R A C T The invention relates to new 6-fluoro-7-chloro-1- -methylamino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid/boric acid anhydrides of the general Formula I Image /I/ (wherein R and R1 stand for halogen; an aliphatic acyloxy group comprising 2-6 carbon atoms and optio- nally substituted by halogen; or an aromatic acyloxy group comprising 7-11 carbon atoms). The new compounds of the general Formula I are valuable intermediates useful in the preparation of the antibacterial agent 6-fluoro-1-ethylamino-7-(4- -methyl-piperazino)-4-oxo-1,4-dihydro-quinoline-3- -carboxylic acid. The new compounds of the general Formula I may be prepared by reacting a compound of the Formula II Image /II/ or a compound of the general Formula III Image /III/ (wherein R2 stands for alkyl comprising 1-4 carbon atoms) with hydrogen fluoro borate of the Formula IV Image /IV/ or a borone trihalide of the general Formula V Image /V/ (wherein X stands for fluorine, chlorine or bromine) or a complex thereof formed with an ether or a borone derivative of the general Formula VI Image /VI/ (wherein R3, R4 and R5 stand for alkyl comprising 1-5 carbon atoms and optionally substituted by halogen or aryl comprising 6-10 carbon atoms).

524729

Affiliated with

Also associated with

Rating

6-fluoro-7-chloro-1-methylamino-4-oxo-1-4-dihydroquinoline... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 6-fluoro-7-chloro-1-methylamino-4-oxo-1-4-dihydroquinoline..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6-fluoro-7-chloro-1-methylamino-4-oxo-1-4-dihydroquinoline... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1210361