6-fluorobicyclo[3.1.0]hexane derivatives

Details 6-fluorobicyclo[3.1.0]hexane derivatives 6-fluorobicyclo[3.1.0]hexane derivatives

C - Chemistry, Metallurgy

07

C

C07C 229/50 (2006.01) A61K 31/198 (2006.01) A61K 31/215 (2006.01) A61K 31/277 (2006.01) A61K 31/381 (2006.01) A61K 31/655 (2006.01) A61P 25/24 (2006.01) C07C 255/54 (2006.01) C07D 333/16 (2006.01)

Patent

CA 2471642

An antidepressant comprising, as an active ingredient, a compound having an antagonistic effect on group II metabotropic glutamate receptors, as well as a 2-amino-3-alkoxy-6-fluoro- bicyclo[3.1.0]hexane-2,6- dicarboxylic acid derivative of Formula [I]: (see formula I) [wherein R1 and R2, which may be the same or different, each represent a hydroxyl group, a C1-10 alkoxy group, etc.; R3 represents a C1-10 acyl group, a C1-6 alkoxy-C1-6 acyl group, etc.; and R4 and R5, which may be the same or different, each represent a hydrogen atom, a C1-10 alkyl group, etc.] or a pharmaceutically acceptable salt or hydrate thereof.

L'invention concerne des antidépresseurs contenant, comme principe actif, des composants qui comportent un antagoniste du récepteur métabotropique du glutamate de type II ; et des dérivés d'acide 2-amino-3-alcoxy-6-fluorobicyclo[3.1.0]-hexane-2,6-dicarboxylique représentés par la formule générale [I], ainsi que des sels pharmaceutiquement acceptables desdits composés ou des hydrates desdits sels. Dans la formule, R?1¿ et R?2¿ peuvent être identiques ou différents et représentent chacun hydroxyle, C¿1-10? alcoxy, ou similaire ; R?3¿ représente C¿1-10? acyle, C¿1-10? alcoxy-C¿1-6? acyle, ou similaire ; et R?4¿ et R?5¿ peuvent être identiques ou différents et représentent chacun hydrogène, C¿1-10? alkyle, ou similaire.

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