C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242.01
C07D 471/04 (2006.01)
Patent
CA 1167842
ABSTRACT OF THE DISCLOSURE The invention relates to novel 6-hydrazono-pyrido [2,1-b]quinazoline-11-ones of formula (I) Image wherein R, R1 and R2 are the same or different and stand for hydro- gen, halogen, nitro, carboxy, nitrile, alkoxy containing 1 to 4 carbon atoms, alkoxycarbonyl containing 1 to 4 carbon atoms in the alkoxy group, alkyl containing 1 to 4 carbon atoms, amino or hydroxy or R and R1 together stand for methylenedioxy, R2 stands for hydrogen, R3 represents hydrogen or alkyl containing 1 to 4 carbon atoms, R4 stands for hydrogen, alkyl containing 1 to 4 carbon atoms, or phenyl substituted by 1 to 3 same or different sub- stituents selected from the group of halogen(s), alkyl, and alkoxy containing 1 to 4 carbon atoms, phenyloxy, hydroxy, nitro, amino, cyano, carboxy, alkoxycarbonyl having 1 to 4 carbon atoms, alkanoyl having 1 to 4 carbon atoms, methylenedioxy, trifluoromethyl, phenyl and dialkylamino having 1 to 4 carbon atoms in the alkyl part or naphthyl or pyridyl and the dotted line stands for an optional double bond. The novel compounds and their salts, geometric and optical isomers and tantomers are useful intermediates in the synthesis of Rutecarpine alkaloids and Rutecarpine analogues.
380416
Breining Tibor
Hermecz Istvan
Horvath Agnes
Kokosi Jozsef
Meszaros Zoltan
Chinoin Gyogyszer - Es Vegyeszeti Termekek Gyara Rt.
Fetherstonhaugh & Co.
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