6-(hydroxymethyl-ethyl)pyridines

Details 6-(hydroxymethyl-ethyl)pyridines 6-(hydroxymethyl-ethyl)pyridines

C - Chemistry, Metallurgy

07

D

C07D 213/55 (2006.01) A61K 31/44 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2209550

The 6-(hydroxymethyl-ethyl)pyridines are prepared by a process in which the 3-hydroxymethylpyridines which are hydroxyl-protected in the 6-position are oxidized to the 3-aldehyde, this is then converted into the corresponding oxoheptenoic acid derivative using a Wittig-Horner reaction, after this the oxo group is reduced to the hydroxyl group and then the isomers are separated by chromatography. The 6-(hydroxymethyl-ethyl)pyridines are suitable as active compounds in medicaments, in particular in medicaments having antiarterio-sclerotic activity.

6-(Hydroxyméthyléthyl)pyridines préparées par une méthode dans laquelle les 3-hydroxyméthylpyridines, protégées en position 6 au niveau de l'hydroxyle, sont oxydées en 3-aldéhydes, lesquels sont convertis ensuite en dérivés de l'acide oxohepténoïque correspondants, grâce à une réaction Wittig-Horner, après réaction du groupe oxo en groupe hydroxyle; les isomères sont ensuite séparés par chromatographie. Les 6-(hydroxyméthyléthyl)pyridines peuvent être des ingrédients actifs dans certains médicaments, utiles notamment contre l'artériosclérose.

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