6-keto and 5-hemiketal-pgf in1.alpha. xx, methyl esters

Details 6-keto and 5-hemiketal-pgf in1.alpha. xx, methyl esters 6-keto and 5-hemiketal-pgf in1.alpha. xx, methyl esters

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 307/935 (2006.01) C07C 405/00 (2006.01) C07D 307/937 (2006.01) C07D 311/94 (2006.01) C07D 313/00 (2006.01)

Patent

CA 1160628

ABSTRACT OF THE DISCLOSURE Prostaglandin (PG1) derivatives having (1) a 9-deoxy- 6,9-epoxy feature as well as 5-iodo,5,6-didehydro, or 6-hemi- ketal or (2) a 6-keto feature are disclosed; including processes for preparing them and the appropriate intermediates; said derivatives having pharmacological activity. Typical 6-keto and 6-hemiketal compounds are represented respectively, by the formulae: Image and Image

349868

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