6-methoxy-2-napthylacetic acid prodrugs for treating...

Details 6-methoxy-2-napthylacetic acid prodrugs for treating... 6-methoxy-2-napthylacetic acid prodrugs for treating...

A - Human Necessities

61

K

A61K 31/085 (2006.01) A61K 31/16 (2006.01) A61K 31/167 (2006.01) A61K 31/21 (2006.01) A61K 31/215 (2006.01) A61K 31/216 (2006.01) A61K 31/235 (2006.01) A61K 31/265 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2389181

The present invention provides therapeutically effective amounts of 6MNA prodrugs. The pharmaceutical composition comprises (1), wherein R is H or COR', wherein R' is selected from the group consisting of C1 to C6 alkyl, (CH2)m O(CH2)n, (CH2)m(OC2H4)p O(CH2)n, (CH2)m(OC2H4)p, (OCH2H4)p ONO2 and (OCH2H4)p O(CH2)n wherein m is an integer from 2 to 4, and n and p are integers from 1 to 4. Alternatively, R is a therapeutic moiety.

L'invention concerne des doses thérapeutiquement efficaces de promédicaments 6MNA. La composition pharmaceutique comprend la formule (1). R est H ou COR'. R' est choisi dans le groupe constitué de C¿1? à C¿6? alkyle, (CH¿2?)¿m?O(CH¿2?)¿n?, (CH¿2?)¿m?(OC¿2?H¿4?)¿p? O(CH¿2?)¿n?, (CH¿2?)¿m?(OC¿2?H¿4?)¿p?, (OC¿2?H¿4?)¿p? ONO¿2? et (OCH¿2?H¿4?)¿p? O(CH¿2?)¿n?. m est un entier de 2 à 4, n et p étant des entiers de 1 à 4. Dans un autre mode de réalisation, R est un groupe caractéristique thérapeutique.

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