6-methylpyridine derivatives, method for preparing thereof...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/12 (2006.01) C07D 213/80 (2006.01)

Patent

CA 2499642

The present invention relates to 6-methylpyridine derivatives useful as an antiviral agent. More particularly, the present invention relates to novel 6- methylpyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), or pharmaceutically acceptable salts thereof, to a method for preparing thereof, and to an antiviral pharmaceutical composition comprising the compound as an active ingredient. The 6- methylpyridine derivatives of the present invention have an excellent inhibitory effect on replication of hepatitis C virus and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.

L'invention concerne des dérivés de 6-méthylpyridine utiles comme agents antiviraux, et plus précisément des dérivés de 6-méthylpyridine, y compris les sels pharmaceutiquement acceptables correspondants, à excellent effet inhibiteur sur la réplication du virus de l'hépatite C (VHC), représentés par la formule I. L'invention concerne également un procédé d'élaboration correspondant, et une composition pharmaceutique antivirale renfermant ce type de composé comme principe actif. Par leur excellent effet inhibiteur sur la réplication du virus de l'hépatite C (VHC), lesdits dérivés peuvent être avantageusement utilisés en tant qu'agents thérapeutiques ou prophylactiques pour l'hépatite C.

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