6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives...

Details 6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives... 6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives...

C - Chemistry, Metallurgy

07

J

167/192, 260/39

C07J 1/00 (2006.01) A61K 31/56 (2006.01) C07J 21/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1309400

A B S T R A C T The invention relates to new 6- or 7-methylenandrosta-1,4- -diene-3,17-diones of the following formula Image wherein R is hydrogen or fluorine; R1 is hydrogen or C1-C6alkyl; R2 is hydrogen or halogen; one of R3 and R4 is =CH2 and the other is hydrogen or C1-C4 alkyl, and when R3 is =CH2, at least one of R and R4 is other than hydrogen; and the symbol -?- represents a double bond and the symbol -?- represents a single bond when R3 is =CH2 or the symbol -?- represents a single bond and the symbol -?- represents a double bond when R4 is =CH2, which are useful in therapy, in particular as anti-cancer agents.

541646

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