6-oxatetracycline and 6-thiatetracycline compounds and...

Details 6-oxatetracycline and 6-thiatetracycline compounds and... 6-oxatetracycline and 6-thiatetracycline compounds and...

C - Chemistry, Metallurgy

07

D

260/328, 260/358

C07D 311/92 (2006.01) C07C 45/71 (2006.01) C07D 215/233 (2006.01) C07D 221/18 (2006.01) C07D 311/22 (2006.01) C07D 311/78 (2006.01) C07D 335/04 (2006.01) C07D 335/06 (2006.01)

Patent

CA 1068285

ABSTRACT OF THE DISCLOSURE Tetracyclic compounds of the formula Image wherein R1 and R2 each are H or alkyl having 1-3 carbon atoms, R3 and R4 each are H, R5 is H, C1, OH, OCH3 or N(CH3)2; and X is O or S; with the proviso that when R5 is methoxy and X is a sulfur atom, R5 is in the 8- or 9-position; and their physiologically acceptable acid addition salts may be prepared by solvolyzing, hydrogenolyzing or hydroxylating certain recited compounds. The products possess broad spectrum anti-bacterial activity, including tetracyline-resistant Gram-positive and Gram-negative organisms.

234780

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