6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives

Details 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives

C - Chemistry, Metallurgy

07

D

C07D 223/18 (2006.01) A61K 31/55 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2676160

The invention relates to 6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl derivatives of Formula (I) wherein R 1, R 2 and R 3 are as defined herein, as .gamma.-secretase inhibitors useful in the treatment of Alzheimer's disease or common cancer including but not limited to cervical carcinomas and breast carcinomas and malignancies of the hematopoietic system.

L'invention concerne des dérivés 6-oxo-6,7-dihydro-5H-dibenzo[b,d]azépin-7-yliques de formule (I), dans laquelle R1, R2 et R3 sont tels que définis ici, en tant qu'inhibiteurs de la .gamma.-secrétase utiles dans le traitement de la maladie d'Alzheimer ou d'un cancer commun dont, mais sans limitation, des cancers cervicaux et des cancers du sein et des tumeurs malignes du système hématopoïétique.

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