C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/205, 260/235
C07C 405/00 (2006.01) A61K 31/557 (2006.01) C07D 309/12 (2006.01)
Patent
CA 1326022
Abstract The invention relates to 6-oxo-prostaglandin-E1 derivatives in accordance with formula I Image (I). where R1 implies the radical COOR2 with R2 having the signifi- cance of a hydrogen atom, a C1-10-alkyl group, a C5-C6- cycloalkyl group or a C6-C10-aryl group or a heterocyclic radical, A implies an E-configurated CH=CH- or -C?C-group, W implies a free or functionally modified hydroxy-methylene group or free or functionally modified Image group in which connection the OH group may in the particular case be in the .alpha. or .beta. position, D implies a straight or branched chain alkylene group with 1 to 5 C atoms, E implies a -C?C-group or a C2-C4-alkenylene group, R3 implies a C1-C10-alkyl-, C3-C10-cycloalkyl or a possibly substitute C6-C10-aryl group or a heterocyclic group, R4 implies a free or functionally modified hydroxy group and, if R2 implies a hydrogen atom, its salts with physiologi- cally tolerated bases as well as the .alpha.-, .beta.- or ?-cyclodex- trin clathrates of the compounds according to formula I. Method for their manufacture and their pharmaceutical use.
561283
Klar Ulrich
Schillinger Ekkehard
Skuballa Werner
Sturzebecher Claus-Steffen
Thierauch Karl-Heinz
Marks & Clerk
Schering Aktiengesellschaft
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