C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 19/00 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2635982
The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4- carbonitrile derivatives having the general Formula (I), to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S and/or cathepsin K related diseases such as osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.
La présente invention concerne des dérivés du 6-phényl-1H-imidazo[4,5-c]pyridine-4-carbonitrile de formule générale (I), des compositions pharmaceutiques comprenant ces dérivés et l~utilisation de ces derniers pour la préparation d~un médicament destiné au traitement de maladies associées à la cathepsine S et/ou à la cathepsine K, telles que l~ostéoporose, l~athérosclérose, l~inflammation et les troubles immunitaires tels que la polyarthrite rhumatoïde, ainsi que la douleur chronique, telle que la douleur neuropathique.
Bennett David Jonathan
Cai Jiaqiang
Cumming Iain
Gillespie Jonathan
Jones Philip Stephen
Fetherstonhaugh & Co.
N.v. Organon
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