6-phenyl-1h-imidazo[4,5-c]pyridine-4-carbonitrile...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2693887

The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula (I), to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such asatherosclerosis,obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer,and chronic pain, such as neuropathic pain.

La présente invention porte sur des dérivés de 6-phényl-1H-imidazo[4,5-c]pyridine-4-carbonitrile ayant la formule générale (I), sur des compositions pharmaceutiques les comprenant, ainsi que l'utilisation de ces dérivés pour la préparation d'un médicament pour le traitement de maladies apparentées à la cathepsine S, telles que l'athérosclérose, l'obésité, l'inflammation et les troubles immunitaires, tels que l'arthrite rhumatoïde, le psoriasis, le cancer et la douleur chronique, telle que la douleur neuropathique.

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