6-phenyl-ih-imidazo [4, 5-c] pyridine-4-carbonitrile...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 17/06 (2006.01) A61P 19/10 (2006.01) A61P 25/02 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2749348

The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4- carbonitrile derivatives having the general Formula (I) to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.

La présente invention porte sur des dérivés de 6-phényl-1H-imidazo[4,5-c]pyridine-4-carbonitrile répondant à la Formule générale (I), sur des compositions pharmaceutiques les contenant ainsi que sur l'utilisation de ces dérivés pour la préparation d'un médicament destiné au traitement de maladies liées à la cathepsine S, telles que l'athérosclérose, l'obésité, une inflammation et des troubles du système immunitaire, notamment la polyarthrite rhumatoïde, le psoriasis, le cancer, et les douleurs chroniques, notamment la douleur neuropathique.

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