C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/34 (2006.01) A61K 31/404 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2387013
The present invention relates to indolinones of general formula (see formula I) substituted in the 6 position, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
Indolinones substituées en position 6, de formule générale (I), dans laquelle R1 A R5 et X sont tels que définis dans la revendication 1, leurs isomères et leur sels, en particulier leurs sels physiologiquement compatibles, qui possèdent des propriétés pharmacologiques précieuses, en particulier un effet inhibiteur sur divers récepteurs tyrosine kinase et complexes cyclines/kinases dépendante des cyclines, ainsi que sur la prolifération de cellules endothéliales et de différentes cellules tumorales, médicaments contenant ces composés, leur utilisation, et procédé de préparation desdits composés.
Heckel Armin
Hilberg Frank
Redemann Norbert
Roth Gerald Jurgen
Spevak Walter
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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