6-pyridin-3-yl-3,4-dihydro-1h-quinolin-2-one derivatives and...

Details 6-pyridin-3-yl-3,4-dihydro-1h-quinolin-2-one derivatives and... 6-pyridin-3-yl-3,4-dihydro-1h-quinolin-2-one derivatives and...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4709 (2006.01) A61K 31/4745 (2006.01) A61P 5/40 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2723545

The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl substituted quinolinone derivatives for the treatment of hyperaldosteronism and/or disorders or diseases that are mediated by 11 .beta.-hydroxylase (CYP11 B1 ).

L'invention porte sur des composés représentés par la formule générale (I) qui sont des inhibiteurs de l'aldostérone synthase humaine et également sur des compositions pharmaceutiques contenant ces composés et sur l'utilisation de ces composés et d'autres dérivés de quinolinone substitués par hétéroaryle pour le traitement de l'hyperaldostéronisme et/ou de troubles ou maladies qui sont à médiation par la 11-ß-hydroxylase (CYP11 B1).

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