6-(pyridinyl)-3(2h)-pyridazinones, their preparation and use...

Details 6-(pyridinyl)-3(2h)-pyridazinones, their preparation and use... 6-(pyridinyl)-3(2h)-pyridazinones, their preparation and use...

C - Chemistry, Metallurgy

07

D

260/264.7

C07D 401/04 (2006.01) C07D 213/04 (2006.01) C07D 213/57 (2006.01)

Patent

CA 1155848

ABSTRACT OF THE DISCLOSURE 2-R-6-PY-3(2H)-pyridazinones (I) or salts thereof, which are useful as cardiotonics, where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, are prepared by reacting 2-R-4,5-dihydro-6-PY-3(2H)-pyridazinone with a dehydrogenating agent. Also shown are: cardiotonic compositions and a method for increasing cardiac contractility using I or salts; and, the pre- paration of the corresponding intermediate 4,5-dihydro compounds.

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