6-(pyridinyl)-3h-imidazo¬4,5-b|pyridines or 6-...

Details 6-(pyridinyl)-3h-imidazo¬4,5-b|pyridines or 6-... 6-(pyridinyl)-3h-imidazo¬4,5-b|pyridines or 6-...

C - Chemistry, Metallurgy

07

D

260/273, 260/246

C07D 471/04 (2006.01) C07D 213/50 (2006.01) C07D 213/61 (2006.01) C07D 213/77 (2006.01)

Patent

CA 1159061

ABSTRACT OF THE DISCLOSURE 2-R2-3-R3-6-PY-S-Q-3H-imidazo[4,5-b]pyridines (I) or 1-R1-2-R2-6- PY-5-Q-1H-imidazo[4,5-b]pyridines (IA) or pharmaceutically-acceptable acid- addition salts thereof, where Q and R2 are each hydrogen or lower-alkyl, R1 and R3 are each hydrogen, lower-alkyl, lower-hydroxyalkyl, 2,3-dihydroxy- propyl, lower-alkoxyalkyl or Y-NB where Y is lower-alkylene having at least two carbon atoms between its connecting linkages and NB is di-(lower-alkyl) amino or 4-morpholinyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl hav- in one or two lower-alkyl substituents, which are useful as cardiotonics, are prepared by reacting 2-R3NH-3-R1NH-S-PY-6-Q-pyridine (II) with a tri- tlower-alkyl)ortho-(lower-alkanoate). Also shown are: the preparation of the intermediates II, as well as intermediates used to prepare II.

374059

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