6-pyridyl-triazolobenzodiazepines

Details 6-pyridyl-triazolobenzodiazepines 6-pyridyl-triazolobenzodiazepines

C - Chemistry, Metallurgy

07

D

260/239.3

C07D 487/04 (2006.01)

Patent

CA 1050020

ABSTRACT OF THE DISCLOSURE Pharmaceutical compositions comprising, in unit dosage form, from about 0.5 mg. to about 100 mg. of a compound of the formula Image I wherein R and R' are hydrogen, methyl or ethyl, R1 is hy- drogen or lower alkyl of 1 through 3 carbon atoms, R2 is hydrogen, lower alkyl of 1 through 3 carbon atoms, fluo- rine, chlorine, bromine, nitro, trifluoromethyl or lower alkylthio of 1 through 3 carbon atoms, and the pharmacolo- gically acceptable acid addition salts thereof, in associ- ation with a pharmaceutical carrier. The process is the administration of the above compositions to humans or ani- mals at a dose of from about 0.01 mg./kg./day to about 2 mg./kg./day for anti-anxiety or anti-depressant effects. -1-

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