6-substituted-1,2,3,4-tetrahydroisoquinolines

Details 6-substituted-1,2,3,4-tetrahydroisoquinolines 6-substituted-1,2,3,4-tetrahydroisoquinolines

C - Chemistry, Metallurgy

07

D

167/226, 260/283

C07D 409/06 (2006.01) A61K 31/47 (2006.01) C07D 217/00 (2006.01) C07D 217/04 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2027325

-30- ABSTRACT Compounds of the formula: Image wherein n = 1 or 2: R1 is lower alkoxy, lower alkyl, halo, ester, carbamate, or substituted amino; and R2 is thienyl or furyl; or R2 is Image wherein R3 and R4 are independently selected from hydrogen, halo, hydroxy, methoxy, thioalkoxy, substituted amino and lower alkyl; and pharmaceutically acceptable salts thereof. These compounds are useful as inhibitors of alpha-2-adrenergic receptors and for the treatment of glaucoma and/or controlling intraocular pressure.

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