6-substituted-2,3,4,5-tetrahydro-1h-benzo[d]azepines as...

Details 6-substituted-2,3,4,5-tetrahydro-1h-benzo[d]azepines as... 6-substituted-2,3,4,5-tetrahydro-1h-benzo[d]azepines as...

C - Chemistry, Metallurgy

07

D

C07D 223/16 (2006.01) A61K 31/55 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2619566

The present invention provides 6-substituted 2,3,4,5-tetrahydro-lH- benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: R6 D R N-R" R* where R6 is -(CrC3)alkyl-S-(C0-C3)alkyl-R10, -(C1-C3)alkyl-NR11R12, -(CrC3)alkyl-O- R 13. and other substituents are as defined in the specification.

La présente invention concerne des 2,3,4,5-tétrahydro-1H-benzo[d]azépines 6-substituées de Formule (I) en tant qu'antagonistes sélectifs du récepteur 5-HT2C destinés au traitement de troubles liés à 5-HT2c, y compris l~obésité, les troubles obsessifs/compulsifs, la dépression, et l~anxiété : R6 D R? N-R' R*, dans laquelle R6 est -(CrC3)alkyl-S-(C0-C3)alkyl-R10, -(C1-C3)alkyl-NR11R12, -(CrC3)alkyl-O-, R13 et les autres substituants étant tels que définis dans la description.

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