6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as...

Details 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as... 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as...

C - Chemistry, Metallurgy

07

D

C07D 223/16 (2006.01) A61K 31/55 (2006.01) A61P 3/04 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/30 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2556390

The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H- benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: I where: R6 is - C=C-R10, -O-R12, -S-R14, or -NR24R25; and other substituents are as defined in the specification.

La présente invention a trait à des 2,3,4,5-tétrahydro-1H-benzo[d]azépines substitués en position 6 de formule (I) dans laquelle : R?6¿ est C.ident.C-R?10¿, -O-R?12¿, -S-R?14¿, ou -NR?24¿R?25¿ et les autres substituants sont tels que définis dans la description, en tant qu'agonistes sélectifs de récepteur 5-HT¿2C? pour le traitement de troubles liés au 5-HT¿2C? comprenant l'obésité, le trouble obsessionnel/compulsif, la dépression et l'anxiété.

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