C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/16 (2006.01) A61K 31/55 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2619287
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H- benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where R6 is -C.ident.C- R10, -CH=CR11R11' , or -(C0-C8)alkyl-Ar2 optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents and other substituents are as defined in the specification.
La présente invention se rapporte à des 2,3,4,5-tétrahydro-1H-benzo[d]azépines substitués en position 6 de formule (I) en tant qu~agonistes sélectifs du récepteur de 5-HT2C pour le traitement des troubles associés au 5-HT2C notamment l~obésité, le trouble obsessionnel/compulsif, la dépression, et l~anxiété : dans laquelle R6 est -C.ident.C-R10, -CH=CR11R11', ou -(C0-C8)alkyl-Ar2 substitué au choix sur le fragment alkyle avec 1 à 6 sustituants fluoro et d~autres substituants tels qu~ils sont définis dans la description.
Allen John Gordon
Briner Karin
Camp Anne Marie
Cases-Thomas Manuel Javier
Hoying Richard Charles
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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