C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/218, 260/258
C07D 239/46 (2006.01) A61K 31/505 (2006.01) C07D 239/54 (2006.01) C07D 239/60 (2006.01)
Patent
CA 1334535
A 6-substituted acyclopyrimidine nucleoside derivative represented by the following general formula I: Image ........I wherein R1 represents a hydrogen or halogen atom or a group of alkyl, alkenyl, alkynyl, alkylcarbonyl, arylcarbonyl, arylcarbonylalkyl, arylthio or aralkyl; R2 represents a group of arylthio, alkylthio, cycloalkylthio, aryl sulfoxide, alkyl sulfoxide, cycloalkyl sulfoxide, alkenyl, alkynyl, aralkyl, arylcarbonyl, arylcarbonylalkyl or aryloxy; R3 represents a hydroxyalkyl group of which alkyl portion may contain an oxygen atom; X represents an oxygen or sulfur atom or amino group; Y represents an oxygen or sulfur atom; and A represents =N- or -NH-, and a pharmaceutically acceptable salt thereof, which are useful as an active ingredient for an antiviral agent, especially antiretroviral agent.
595345
Baba Masanori
de Clercq Erik Desire Alice
Miyasaka Tadashi
Tanaka Hiromichi
Ubasawa Masaru
Baba Masanori
de Clercq Erik Desire Alice
Goudreau Gage Dubuc
Mitsubishi Chemical Corporation
Miyasaka Tadashi
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