6-substituted amino-4-oxa-1-azabicyclo¬3,2,0|heptan-7-one...

Details 6-substituted amino-4-oxa-1-azabicyclo¬3,2,0|heptan-7-one... 6-substituted amino-4-oxa-1-azabicyclo¬3,2,0|heptan-7-one...

C - Chemistry, Metallurgy

07

D

C07D 503/00 (2006.01) A61K 31/42 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 38/05 (2006.01) C07D 519/06 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2252086

Novel 6-substituted amino-4-oxa-1-azabicyclo[3,2,0] heptan-7-one compounds, as well as the pharmaceutically acceptable salts thereof and diastereoisomers thereof, of formula (I) are disclosed, which exhibit excellent cysteine protease inhibitory activity and my be used for treatment of different diseases such as muscular dystrophy, arthritis, myocardial infarction, Alzheimer's disease, bacterial infection, common cold, osteroporosis and cancer metastasis.

La présente invention concerne des composés d'amino-4-oxa-1-azabicyclo [3,2,0] heptan-7-one 6-substituée, ainsi que certains de leurs sels galéniques et de leur diastéréoisomères représentés par la formule générale (I), et qui, faisant preuve d'une très bonne activité inhibitrice de la cystéine protéase, conviennent particulièrement au traitement de différentes affections, et notamment la myopathie primitive progressive, l'arthrite, l'infarctus du myocarde, la maladie d'Alzheimer, l'infection bactérienne, le rhume de cerveaux, l'ostéoporose et les métastases cancéreuses.

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