6-substituted hexahydroindazolo (7,6,5,-1j) isoquinolines...

C - Chemistry – Metallurgy – 07 – D

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260/282.5

C07D 221/14 (2006.01)

Patent

CA 1187883

Abstract of the Disclosure 6-Substituted hexahydroindazolo or hexahydro- isoindolo isoquinolines, having dopamine agonist and dopamine antagonist activity, are described herein. The compounds are prepared by reacting the corresponding 8-dimethylaminomethylene derivative with a substituted amine. Novel intermediates are also disclosed; these intermediates are of the formula Image II wherein R is H, (Cl-C3)alkyl, allyl or benzyl; and R4 and R5 are independently H or (Cl-C3)- alkoxy.

457635

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