C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/404 (2006.01) A61P 27/00 (2006.01) C07D 401/06 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2674946
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1 -phosphate receptor agonist and or antagonist biological activity: Formula (I) and wherein the variables Y, R4, n, o, A, A1, A2, X, Z, R1, R3, R2, p, q and r are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing
L'invention concerne des composés représentés par la formule I, dont chacun peut avoir une activité biologique d'agoniste et/ou d'antagoniste de récepteur de sphingosine-1-phosphate: formule (I) et où les variables Y, R4, n, o, A, A1, A2, X, Z, R1, R3, R2, p, q et r sont telles que définies dans le mémoire. Ces composés sont utiles pour le traitement d'une maladie ou d'un état choisi dans le groupe constitué d'un glaucome, de la sécheresse oculaire, de l'angiogenèse, de troubles et maladies cardiovasculaires, et de cicatrisation de plaie.
Beard Richard L.
Yuan Haiqing
Allergan Inc.
Gowling Lafleur Henderson Llp
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