6-substituted isoquinolines and isoquinolinones

Details 6-substituted isoquinolines and isoquinolinones 6-substituted isoquinolines and isoquinolinones

C - Chemistry, Metallurgy

07

D

C07D 217/24 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61P 9/12 (2006.01) A61P 43/00 (2006.01) C07D 217/02 (2006.01) C07D 217/22 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2728128

The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho- kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

Cette invention concerne des dérivés de lisoquinoline et de lisoquinolinone à substitution en 6 de formule (I) utilisés dans le traitement et/ou la prévention des maladies associées avec la Rho-kinase et/ou la phosphorylation par lintermédiaire de la Rho-kinase de la phosphatase des chaînes légères de myosine, et des compositions contenant ces types de composés.

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