6-substituted mitomycin analogs

Details 6-substituted mitomycin analogs 6-substituted mitomycin analogs

C - Chemistry, Metallurgy

07

D

167/240, 260/299

C07D 487/14 (2006.01) A61K 31/405 (2006.01)

Patent

CA 1249278

"NEW 6-SUBSTITUTED MITOMYCIN ANALOGS" ABSTRACT Novel methods for treatment of neoplastic disease states in animals, which methods comprise admin- istering a therapeutically effective amount of a compound of the formula IV, Image IV wherein: Y is hydrogen or lower alkyl; and Z is a radical of the formula -O-R, wherein R is: a substituted lower alkyl radical selected from the group consisting of mono- and di-hydroxy lower alkyl, cyano lower alkyl, halo lower alkyl, lower alkyl amino lower alkyl, hydroxy lower alkylthio lower alkyl, hydroxy lower alkyldithio lower alkyl, di-lower alkoxy lower alkyl, hydroxy or lower alkoxy substituted lower alkoxy lower alkyl, and cyclo lower alkyl substituted lower alkyl; or a lower alkenyl radical; or a lower alkynyl radical; or a substituted or unsubstituted oxygen-containing heterocyclic radical selected from the group consisting of tetrahydro furanyl or lower alkyl substituted deriva- tives thereof, lower alkyl substituted oxiranyl, lower alkyl substituted dioxolanyl, lower alkyl substituted pyranyl, or lower alkyl substituted furfuryl.

487369

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