C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07D 239/00 (2006.01) C07D 249/00 (2006.01)
Patent
CA 2539252
This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. The present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
L'invention concerne certains composés 6-[(substituées)phényl]triazolopyrimidine ou leurs sels pharmaceutiquement acceptables, et des compositions contenant lesdits composés ou leurs sels pharmaceutiquement acceptables. Les composés de l'invention sont des agents anticancéreux utilisés pour le traitement du cancer chez les mammifères. L'invention concerne également un procédé pour traiter ou inhiber la croissance des cellules tumorales cancéreuses et des maladies associées chez un mammifère, ainsi qu'un procédé pour traiter ou prévenir des tumeurs cancéreuses exprimant une résistance aux médicaments (MDR) ou qui sont résistants à cause d'une MDR, chez un mammifère nécessitant le traitement. Ledit procédé comprend l'administration à un mammifère d'une quantité efficace desdits composés ou de leurs sels pharmaceutiquement acceptables. L'invention concerne, en outre, un procédé pour traiter ou inhiber la croissance de cellules tumorales cancéreuses et des maladies associées chez un mammifère nécessitant le traitement, comprenant la l'activation d'une polymérisation du microtubule, comprenant l'administration à un mammifère d'une quantité efficace desdits composés et de leurs sels pharmaceutiquement acceptables.
Ayral-Kaloustian Semiramis
Nguyen Thai Hiep
Tong Wei
Wu Yanzhong
Zhang Nan
Torys Llp
Wyeth Holdings Corporation
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