6-substituted pyrazolo [3,4-d¦ pyrimidin-4-ones and...

Details 6-substituted pyrazolo [3,4-d¦ pyrimidin-4-ones and... 6-substituted pyrazolo [3,4-d¦ pyrimidin-4-ones and...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2211669

6-Substituted pyrazolo [3,4-d] pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for a) effecting c-GMP- phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.

On décrit des dérivés de pyrazolo [3,4-d] pyrimidin-4-one à substitution en position 6, des compositions pharmaceutiques les contenant et des procédés les utilisant pour a) inhiber la c-GMP-phosphodiestérase, b) traiter l'insuffisance cardiaque et/ou l'hypertension, c) inverser ou réduire la tolérance induite par le nitrate et d) traiter l'angine de poitrine, les maladies cardiaques congestives et l'infarctus du myocarde.

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