6-substituted pyridoindolone derivatives production and...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/407 (2006.01) A61K 31/437 (2006.01)

Patent

CA 2562561

The invention relates to compounds of formula (I), where R¿1? = H, C¿1?-C¿4? alkyl, -(CH¿2?)¿m?OH, -(CH¿2?)¿m?CN, or -(CH¿2?)¿m?NR¿9?R¿10?, R¿2? =H, or C¿1?-C¿4? alkyl, R¿3? = phenyl substituted by R¿6?, R¿7?, or R¿8?, R¿4? = a group of formula (a), a heterocyclic group selected from formulae (b), (c), or (d) and R¿5? = H, or C¿1?-C¿4? alkyl. The invention further relates to a production method and therapeutic application thereof.

La présente invention a pour objet des composés répondant à la formule (I) : dans laquelle, - R1 représente un atome d'hydrogène ; un groupe (C1-C4)alkyle ; un groupe -(CH2)mOH ; un groupe -(CH2)mCN ; un groupe -(CH2)mNR9R10 - R2 représente un atome d'hydrogène ou un groupe (C1 -C4)alkyle ; - R3 représente un phényle substitué par R6, R7, R8 ; - R4 représente un groupe (Formule (a)); un radical hétérocyclique choisi parmi (Formules (b) (c), (d)) : - R5 représente un atome d'hydrogène ou un groupe (C1-C4)alkyle. Procédé de préparation et application en thérapeutique.

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