C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/38 (2006.01) A61K 31/4709 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2713998
The present invention is directed to 6-substituted-thio-2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and / or demen-tia. The compounds of the present invention are inhibitors of .beta.- secretase, also known as .beta.- site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.
L'invention concerne des dérivés de quinoline 6-substituée-thio-2-amino-quinoline, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement de la maladie d'Alzheimer (AD), des troubles cognitifs légers, de la sénilité et/ou de la démence. Les composés de la présente invention sont des inhibiteurs de la ß-sécrétase, également désignée sous le nom d'enzyme de clivage de l'amyloïde ß, BACE, BACE1, Asp2, ou mémapsine2.
Baxter Ellen
Creighton Christopher J.
Lu Tianbao
Morgan Ross Tina
Reitz Allen B.
Janssen Pharmaceutica N.v.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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