6-thioxanthines

Details 6-thioxanthines 6-thioxanthines

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/22 (2006.01) A61K 31/52 (2006.01)

Patent

CA 1276147

ABSTRACT A 6-thioxanthine of general formula I or a pharmaceutically acceptable salt thereof Image I wherein R3 is a C2 to C6 alkyl, a C3 to C7 cycloalkyl group or a C4 to C8 cycloalkylalkyl group and R8 is a C1 to C6 alkyl, a C3 to C7 cycloalkyl group or a C4 to C8 cycloalkylalkyl group provided that when R3 is an ethyl, n-propyl or n-butyl group, R8 is a C3 to C6 alkyl, a C3 to C7 cycloalkyl group or a C4 to C8 cycloalkylalkyl group. These 3,8-disubstituted-6-thioxanthines have enhanced bronchodilator activity.

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