6-¬triazolyl¬3-(trifluoromethyl)phenyl¦methyl¦-2-quinolinone...

Details 6-¬triazolyl¬3-(trifluoromethyl)phenyl¦methyl¦-2-quinolinone... 6-¬triazolyl¬3-(trifluoromethyl)phenyl¦methyl¦-2-quinolinone...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/47 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2207268

This invention is concerned with the compounds of formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, amino or C1-4alkyl; R2 is hydrogen, halo or C1-4alkyl; R3 is hydrogen, halo or C1-4alkyl; Y is O or S, and -X1 = X2- is a bivalent radical having the formula: -N = CH- (a-1) or -CH = N- (a-2); compositions containing the same, and processes of preparing these compounds. It further relates to their use as a medicine, in particular their use as a medicine to treat keratinization disorders.

Cette invention se rapporte à des composés de la formule (I), aux sels d'addition d'acide pharmaceutiquement acceptables et aux formes stéréochimiquement isomères de ceux-ci, formule dans laquelle R?1¿ représente hydrogène, amino ou alkyle C¿1-4?; R?2¿ représente hydrogène, halo ou alkyle C¿1-4?; R?3¿ représente hydrogène, halo ou alkyle C¿1-4?; Y représente O ou S et -X?1¿=X?2¿- représente un radical bivalent ayant la formule -N=CH- (a-1) ou -CH=N- (a-2); cette invention se rapporte également aux compositions contenant ces composés et aux procédés de préparation de ces derniers. Elle se rapporte également à leur utilisation en médecine et notamment à leur utilisation comme médicaments pour traiter les troubles de la kératinisation.

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