66 kda antigen from borrelia

Details 66 kda antigen from borrelia 66 kda antigen from borrelia

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/116 (2006.01) A61K 39/40 (2006.01) A61K 48/00 (2006.01) C07K 14/20 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2193641

Nucleic acid fragments are disclosed which encode a polypeptide antigen reactive with antisera from rabbits immunised with a 66 kDa protein from Borrelia garinii IP90. The presence of nucleic acid fragments encoding such a polypeptide antigen as well as the presence of the polypeptide antigen have been demonstrated in three strains of B. Burgdorferi sensu lato, but are substantialle absent from at least 95 % of randomly selected B. hermsii, B. crocidurae, B. anserina, and B. hispanica. The encoded polypeptide is surface exposed on the bacterial surface, it is highly conserved, and is thus potentially useful as a vaccine agent and as a diagnostic agent in the diagnosis of infections with B. burgdorferi as are the characteristic nucleic acid fragments of the invention. Also disclosed are methods of producing the polypeptide antigen according to the invention as are antibodies directed against the antigen.

L'invention concerne des fragments d'acide nucléique qui codent un antigène polypeptide réactif avec des antisérums de lapins immunisés avec une protéine 66kDa provenant de Borrelia garinii IP90. La présence de fragments d'acide nucléique codant un tel antigène polypeptide ainsi que la présence de l'antigène polypeptide ont été démontrées dans trois souches de B. Burgdorferi sensu lato. Toutefois, ils sont sensiblement absents dans au moins 95 % de B.hermsii, B. crocidurae, B. Anserina et B. hispanica. Le polypeptide codé est exposé en surface sur la surface bactérienne; il est fortement conservé et est utile comme vaccin ou comme agent de diagnostic pour diagnostiquer des infections par le B. burgdorferi, de même que les fragments caractéristiques de l'acide nucléique de la présente invention. L'invention traite également de procédés de production de l'antigène polypeptide selon l'invention, et d'anticorps dirigés contre cet antigène.

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