6b, 17-dihydroxy-7.beta.-(lower alkoxy)...

Details 6b, 17-dihydroxy-7.beta.-(lower alkoxy)... 6b, 17-dihydroxy-7.beta.-(lower alkoxy)...

C - Chemistry, Metallurgy

07

J

260/21, 260/39

C07J 21/00 (2006.01) C07J 1/00 (2006.01)

Patent

CA 1071620

Abstract Or the Disclosure The present invention is concerned with 6.beta.,17- dihydroxy-7.alpha.-(lower alkoxy)carbonyl-3-oxo-17.alpha.-pregn-4- ene-21-carboxylic acid .gamma.-lactones and their corresponding hydroxy acids and salts. The lactones of this invention are prepared by oxidizing the dienol ether intermediates with a suitable peroxy acid in the presence of an aqueous organic solvent. These compounds possess diuretic activity as evidenced by their ability to re- verse the errect of desoxycorticosterone acetate on urinary sodium and potasium,

261650

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