6h-dibenz[b,e][1,4]oxathiepin compounds

Details 6h-dibenz[b,e][1,4]oxathiepin compounds 6h-dibenz[b,e][1,4]oxathiepin compounds

C - Chemistry, Metallurgy

07

D

260/301, 260/306

C07D 327/02 (2006.01) C07D 411/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 1230124

Abstract of the disclosure The present invention relates to 6H-dibenz[b,e][1,4] oxathiepin derivatives having the following formula I or Ia: Image Image I Ia wherein Z is a member selected from the group consisting of thio, sulfinyl or sulfonyl; R2 and R3 are the same or different and are members selected from the group consisting of hydrogen, halogen, nitro, loweralkyl, amino, N-loweralkylamino, N,N-diloweralkylamino, loweralkanoyl, hydroxy, loweralkoxy, loweralkylthio, trifluoro- methylthio, loweralkylsulfinyl, loweralkylsulfonyl or trifluoro- methyl; and R1 is a member selected from the group consisting of 5-tetrazolyl, 5-tetrazolylmethyl, 3-hydroxy-1,2-5-thiadiazol-4-yl, 4-hydroxy-.DELTA.3-pyrroline-3-yl-2,5-dione, or Image wherein n is an integer from 0-4 and R4 is a member selected from the group consisting of hydroxy, loweralkoxy, N,N-diloweralkylamino- loweralkoxy, hydroxyloweralkoxy, carboxyloweralkoxy, amino, N-loweralkylamino, N,N-diloweralkylamino, loweralkylsulfonylamino, carboxyloweralkylamino, carboxamidoloweralkylamino, 2-imino-3- methylthiazolidine, loweracyloxyloweralkoxy, and the pharmaceuti- cally acceptable salts thereof, employed in the treatment and control of allergic conditions such as allergic asthma.

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