6h-dibenz [b,e] [1,4] oxathiepin derivatives

Details 6h-dibenz [b,e] [1,4] oxathiepin derivatives 6h-dibenz [b,e] [1,4] oxathiepin derivatives

C - Chemistry, Metallurgy

07

D

260/327.7

C07D 327/02 (2006.01)

Patent

CA 1208653

ABSTRACT OF THE DISCLOSURE Novel 6H-dibenz [b,e][1,4] oxathiepin deriva- tives of the formulae I and IA are employed in the treatment and control of allergic conditions such as allergic asthma. Image Image I IA wherein n is an integer of from 1-4; Z is thio, sulfinyl, or sulfonyl; R1, R2 and R3 are each independently se- lected from hydrogen, halogen, amino, Cl to C4 alkyl, Cl to C4 alkylthio, Cl to C4 alkylsulfinyl, Cl to C4 alkylsulfonyl, trifluoromethyl, trifluoromethylthio, cyano, nitro, and Cl to C4 alkyl or dialkylamino, Cl to C4 alkoxy, Cl to C4 alkanoyl, aralkyl, or hydroxy Cl to C4 alkyl; R4 is H, Cl to C4 acyl, Cl to C4 alkylamino- acyl, Cl to C4 alkylcarboxy, Cl to C4 alkylcarboxamido, Cl to C4 alkylcarboxamidoacyl or Cl to C4 acyloxy Cl to C4 alkyl; R1 and R2 can also be an unsubstituted C2 to C6 polymethylene chain, or said chain is substituted with a hydroxy or keto group.

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